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Acute graft-versus-host disease histopathological grading
| Grade | Definition |
|---|---|
| 1 | Focal or diffuse vacuolar alteration of basal cells |
| 2 | Vacuolar alteration of basal cells; spongiosis and dyskeratosis of epidermal cells |
| 3 | Formation of subepidermal cleft in association with dyskeratosis and spongiosis |
| 4 | Complete loss of epidermis |
Adapted from Lerner et al. [55]
