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. 2018 Jan 30;9:63. doi: 10.3389/fmicb.2018.00063

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Copyright © 2018 Schmid, Muri, Melidis, Varadarajan, Somerville, Wicki, Moser, Bourqui, Wenzel, Eugster-Meier, Frey, Irmler and Ahrens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Statistics of the L. helveticus pan- and core genome based on 12 completely sequenced strains. (A) Number of gene clusters for pan (dashed line) and core genome profile (straight line) when successively adding genomes. The curves show mean values of 10 iterations where genomes were randomly added and the pan and core genome was calculated successively for all 12 steps. (B) Number of gene clusters (reflected by the size of the respective areas) for core, accessory, pan and unique genome.