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. 2018 Jan 30;9:25. doi: 10.3389/fneur.2018.00025

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Copyright © 2018 Yang, Chou, Hsu, Fuh, Lirng, Kao, Lin and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NBS identify the set of abnormal functional connections between study groups. Illustration of the network with reduced FC in two patient groups (compared to CRL group). Node colors correspond with the different functional subsystems. (A) Compared to CRL, MIG w/o RLS showed reduced FC in the network with eight nodes and seven edges, and (B) MIG w RLS showed reduced FC in the network with nine nodes and eight edges. Abbreviations: CRL, healthy controls; FC, functional connectivity; MIG w/o RLS, migraine without restless legs syndrome; MIG w RLS, migraine with restless legs syndrome; NBS, network-based statistics; FWE, family-wise error.