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NT-1654 improves overall state of wellbeing. (A) Body weight evaluation during time (PBS WT n = 20, NT-1654 SMA n = 27, PBS SMA n = 15). (B) Event time plot for body weight deviation of PBS SMA, NT-1654 SMA and PBS WT (Kaplan–Meier curve, Log-rank Mantel Cox test, P < 0.05). (C) Kaplan–Meier survival curve shows that NT-1654 can significantly extends SMA lifespan (PBS SMA n = 20, NT-1654 SMA n = 19; Log-rank statistical test, P < 0.05).
