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. 2018 Jan 30;9:86. doi: 10.3389/fimmu.2018.00086

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Copyright © 2018 Hoffmann, Machelart, Song and Brodin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phagosomal functions after internalization of non-pathogenic bacteria (left panel) and in the context of Mtb infection (right panel). Schematic representation of the key players and main functional features after the uptake of non-pathogenic bacteria leading to the clearance of the internalized cargo (left panel). Upon Mtb infection, the pathogen is internalized into mycobacteria-containing vacuoles (MCVs), which are delayed in phagosome maturation (right panel). Some of the altered phagosomal functions are indicated here together with involved host molecules that were identified by MS approaches (references shown in red) or by non-MS techniques (references shown in black). Abbreviations: CathD, cathepsin D; CathS, cathepsin S; Cish, cytokine-inducible SH2-containing protein; EE, early endosome; EEA1, early endosomal antigen 1; Ifitm3, interferon-induced transmembrane protein 3; LAMP2, lysosome-associated membrane protein 2; LE, late endosome; LYS, lysosome; MHC, major histocompatibility complex; MR, mannose receptor; MS, mass spectrometry; Mtb, Mycobacterium tuberculosis; Nramp-1, natural resistance-associated macrophage protein 1; PI3P, phosphatidyl-inositol-3-phosphate; PR, phagocytic receptor; TfR, transferrin receptor; TLR, toll-like receptor; V-ATPase, vacuolar proton ATPase.