(A) Mass spectrometry (MS) data of total cellular host proteins |
Shui et al. (21) |
Cellular extract |
J774.A1 treated by Mycobacterium tuberculosis (Mtb) lipid extract |
iTRAQ/SILAC |
166 |
Immune response, oxidation and reduction, signal transduction, vesicle transport, metabolism, etc. |
Yu et al. (22) |
Lung tissue |
Mtb-infected patient tissue, negative for HIV and HBV |
Label-free |
6 Mtb peptides |
Identification of novel Mtb antigens from granuloma lesions, antigen-specific IFN-γ secretion, and functional CTL responses |
Kaewseekhao et al. (23) |
Cellular extract/supernatant |
THP-1 infected by Mtb H37Rv (MOI 1; 1–5 days) |
Label-free |
283 |
Cell cycle, antimicrobial and inflammatory responses, DNA replication, etc. |
Li et al. (24) |
Cellular extract |
THP-1 infected by Mtb H37Rv/H37Ra or beads (MOI 35; 12 h) |
TMT |
235 |
Apoptosis, blood coagulation, and oxidative phosphorylation |
Li et al. (25) |
Cellular extract |
THP-1 infected by BCG/Mycobacterium bovis/Mtb H37Rv (MOI 10; 24 h) |
iTRAQ |
61 |
Phagosome maturation and TNF signaling |
|
(B) MS data of cell organelle proteins |
Wang et al. (26) |
Cytoplasm and nucleus |
RAW264.7 infected by Mycobacterium marinum (MOI 10; 4 h) |
AACT/SILAC |
1,429 |
Toll-like receptor 2-inflammatory responses, major histocompatibility complex-I processing and presentation, and transcriptional factors |
Saquib et al. (27) |
Endoplasmic reticulum |
THP-1 infected by Mtb H37Rv/H37Ra (MOI 10; 12 h) |
SILAC |
133 |
Cytosolic Ca2+ levels, apoptosis, and cholesterol homeostasis |
Diaz et al. (28) |
Exosome |
THP-1 infected by Mtb H37Rv (MOI 5; 24 h) |
Biotinylated |
41 |
Analysis of the exosome content |
Kumar et al. (29) |
Secretome |
THP-1 infected by Mtb H37Rv/H37Ra/BND433/JAL2287 (MOI 10; 6–26 h) |
iTRAQ |
n/a |
Analysis of the secretome |
Kuo et al. (30) |
Cell and plasma membrane |
THP-1 derived DCs treated by heat-killed Mtb powder (10 µg/ml; 3 days) |
Deuterium |
115 |
Aminopeptidase N (ANPEP, CD13) |
Long et al. (31) |
Plasma membrane |
THP-1 infected by BCG (MOI 5; 4 h) |
SILAC |
559 |
Immune interactions and lipid metabolism |
|
(C) MS data of MCVs and phagosomes |
Rao et al. (32) |
Phagosome |
BMA.A3 infected by Mtb H37Rv/H37Rv ΔfbpA/BCG (MOI 5; 18 h) |
Label-free |
322 |
Phagosome maturation and role of the ER in phagosome biogenesis |
Lee et al. (33) |
Phagosome |
THP-1 infected by BCG or beads (MOI 80; 3 h–5 days) |
SYPRO Ruby |
447 |
Membrane trafficking and signal transduction |
Shui et al. (34) |
Phagosome |
RAW264.7 incubated with beads coated with ManLAM/PILAM/LPS |
iTRAQ |
42 |
Vesicle trafficking, phagosome maturation, and autophagosome |
Li et al. (35) |
Phagosome |
BMDM and BMDC infected by Mtb H37Rv (MOI 5; 18 h) |
Label-free |
41 |
Phagosome maturation and antigen presentation |
Herweg et al. (36) |
Phagosome |
RAW264.7 incubated with Mtb or trehalose-dimycolate-coated beads for 30 min |
Label-free |
835 |
Mitochondria, cytoskeleton, plasma membrane, ER, endosome, and Golgi-associated proteins |