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. 2018 Jan 30;9:35. doi: 10.3389/fmicb.2018.00035

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Copyright © 2018 Botero, Alvarado, Bernal, Danies and Restrepo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type of networks. (A) Directed networks are composed of nodes representing biological entities as proteins, metabolites, or genes. These nodes are interconnected by directed edges (or arrows) that symbolize a directed relationship between two or more biological species, as a gene regulated by a transcription factor or a reaction that is connected downstream to another reaction forming metabolic pathways. (B) Undirected networks are composed of nodes, that represent proteins, for example. These nodes are interconnected by edges that symbolize an interaction between two or more biological species, as for example signaling proteins.