Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 30;9:29. doi: 10.3389/fmicb.2018.00029

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Ye, Su, Lin, Lai, Li, Ali, Zheng and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proposed model for the dual roles of alanine in facilitating kanamycin to kill antibiotic-resistant bacteria. Exogenous alanine facilitates kanamycin to kill antibiotic-resistant bacteria through increased kanamycin uptake, and enhanced ROS production. Meanwhile, alanine decreased the transcription of oxyR, which plays essential role in positively regulating antioxidant enzymes. Thus, the enhanced ROS production was achieved through FADH₂ oxidation and repression of antioxidant function genes via OxyR in an unidentified manner. Red represents increase and blue represents decrease.