Figure 1.

THR (target hit-rate) of bitter compounds toward human TAS2Rs (black bars) and chicken ggTas2r1, ggTas2r2, ggTas2r7 (blue, orange, and green bars, respectively). THR parameter is the number of targets hit at a specific concentration divided by the number of targets tested (Azzaoui et al., 2007; Di Pizio and Niv, 2015). Specifically, only compounds that elicited receptor activation of both human TAS2Rs and ggTas2rs at concentration of 300 μM or lower were used to generate this graph.