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. 2018 Jan 31;9:85. doi: 10.3389/fmicb.2018.00085

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Copyright © 2018 Djokic, Akoolo and Parveen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of B. microti infection on spleen of the infected mice. (A) B. microti infection resulted in a significant increase in spleen sizes of mice compared to uninfected, naïve mice. (B) White and red pulp zones were significantly enlarged while demarcation zone was not apparent in the spleen of B. microti infected mice. Numbers of lysed erythrocytes (marked by arrowheads) as well as various free parasitic forms (marked by arrows) were also observed in infected mouse spleen. (C) In IFA conducted the spleen section, red color indicates auto-fluorescence of RBCs, blue shows nuclear staining of cells while green fluorescence marks B. microti probed with infected human plasma followed by detection with Alexa fluor 488 conjugated secondary antibodies. Apparent lysed infected erythrocytes presence is marked by a circle. Several free, released parasitic forms were also detected (marked by arrows) among erythrocytes. Bars represent 25 μm.