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. 2018 Jan 31;9:43. doi: 10.3389/fphar.2018.00043

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Copyright © 2018 Hong, Cai, Xu, Cao, Yu, Zhao, Huang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Other major enzymes of the PPP did not participate in the cisplatin resistance of A549/DDP cells. (A,B) The mRNA and total protein levels of PGD, TKT and TALDO1 were assessed in A549 and A549/DDP cells. The control GAPDH band is shown in Figure 3B. (C,D) A549/DDP cells transfected with siRNA were cultured for 48 h with various concentrations of cisplatin (3.125–200 μM), and cell viability was determined. Data are represented as the means ± SD (n = 3), and significant differences are indicated as ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.