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. 2018 Jan 31;11:12. doi: 10.3389/fnmol.2018.00012

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Copyright © 2018 Vejux, Namsi, Nury, Moreau and Lizard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oxysterols in various neurodegenerative diseases. Based on recent results (in vitro, in vivo, or clinical studies), the use of oxysterols as biomarkers is reinforced in various neurodegenerative diseases, whether demyelinating (multiple sclerosis, peroxisomal leukodystrophies) or non-demyelinating (Niemann–Pick disease, Alzheimer’s disease, Parkinson’s disease, and Huntington disease). For amyotrophic lateral sclerosis, it can also be hypothesized that oxysterols can be used as biomarkers, particularly 25-hydroxycholesterol and 24S-hydroxycholesterol, as well as phytosterols such as β-sitosterol and its glucoside derivatives.