Table 3.
Association results of rs139944387
| Chr. | SNP ID | Position | Gene | Allele (1/2)a | Stage | Risk allele | Case | Control | P‐value | Odds ratio (95% CI) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Genotype | |||||||||||||||||||
| 11 | 12 | 22 | RAF | 11 | 12 | 22 | RAF | Allelic | Dominant | Recessive | Allelic | Dominant | Recessive | |||||||
| 6 | rs139944387 | 64,430,690 | EYS | T/C | Screening | C | 6 | 3 | 0 | 0.167 | 1118 | 23 | 0 | 0.010 | .00094 | .00079 | 1.00 | 19.6 (5.3‐72.5) | 24.3 (5.7‐103.2) | NA |
| Replication | 9 | 1 | 0 | 0.050 | 221 | 3 | 0 | 0.007 | .16 | .16 | 1.00 | 7.8 (0.8‐78.6) | 8.2 (0.8‐86.6) | NA | ||||||
| Combined | 15 | 4 | 0 | 0.105 | 1339 | 26 | 0 | 0.010 | .00064 | .00056 | 1.00 | 12.2 (4.0‐37.0) | 13.7 (4.3‐44.2) | NA | ||||||
Chr., chromosome; CI, confidence interval; NA, not available; RAF, risk allele frequency; SNP, single nucleotide polymorphism.
a
Major allele in control is defined as allele 1.