Figure 5.

PRIMA‐1 suppresses tumor growth in esophageal squamous cell carcinoma (ESCC) cell line (TE8) xenograft mice with a TP53 missense mutation. A, The growth curves, tumor weight, and images of TE8 tumors from xenograft mice treated with control (PBS) vs PRIMA‐1; n = 5 for each group. Error bars show the SEM. P‐values refer to the comparison of PRIMA‐1‐treated samples with untreated samples. *P < .05. B, HE staining or immunohistochemical staining for apoptotic markers, cleaved PARP and caspase‐3 of tumor sections treated with control and PRIMA‐1. C, Western blot analysis of xenografts treated with control and PRIMA‐1 for 3 days