Figure 2.

Family trees of 3 patients with minor variants. (A) A 73‐year‐old woman with breast cancer was found to have BRCA1 p.Val271Met with C‐score of 24. Her daughter with ovarian cancer had genetic counseling and testing showed the same variant. She suffered from recurrent serous adenocarcinoma of the ovary. B, A 45‐year‐old woman with breast cancer was found to have BRCA2 p.Lys322Gln with C‐score of 16.89. This variant was identified in 6 patients with breast cancer. Her sister with breast cancer was referred to genetic counseling and testing showed her not to have the same variant. C, A 71‐year‐old woman with breast cancer had a variant of BRCA1 p.Met1628Thr with C‐score of 0.023. This variant was not documented in the ClinVar database. Her daughter was referred to genetic counseling and testing. This variant was not found in the daughter, so the pathogenicity was defined to be low