Figure 1.

Expression features and functional annotations of proliferation‐related genes involved in lung development (PTN1 genes). A, Expression levels of PTN1 genes are presented as box diagrams. The sample types are plotted on the x‐axis, and the normalized average gene expression level in every sample type is plotted on the y‐axis. EarlyL, early embryonic lung at 6‐8 postovulatory weeks (PWs); MatureL, adult cancer‐free peripheral lung tissue subject to surgery for benign lung diseases; MiddleL, middle embryonic lung at 16‐4 PWs; PC, paracancerous; WholeE, whole embryos at 3‐5 PWs. B, Histogram displays the distribution of PTN1 genes in 69 lung adenocarcinoma (ADC) samples (ADC_Ours) and 69 lung squamous cell carcinoma (SCC) samples (SCC_Ours), with MatureL as the control. The count of PTN1 genes is plotted on the y‐axis, and the proportions of upregulated (red), downregulated (blue), and unregulated (yellow) genes are marked on the columns. C, The most significantly enriched functional categories of PTN1 genes are mainly related to cell proliferation ADC: lung adenocarcinoma; SCC: lung squamous cell carcinoma