Table 1.
Epstein‐Barr virus (EBV) gene expression and viral latency
| EBV latency | EBV gene transcription | Infected cell types and tumors |
|---|---|---|
| Type 0 | EBERs | Memory B cell |
| Type I | EBERs, EBNA1, BARTs | Burkitt's lymphoma |
| Type II | EBERs, EBNA1, BARTs, LMP1, LMP2 | Nasopharyngeal carcinoma, gastric cancer,a Hodgkin's lymphoma, NK/T lymphoma |
| Type III | EBERs, EBNA1, EBNA‐LP, EBNA2, EBNA3A‐C, BARTs, LMP1, LMP2 | Lymphoblastoid cell (infectious mononucleosis), post‐transplant lymphoproliferative disease, patients with immunosuppression |
BART, BamHI A rightward transcript; EBER, EBV‐encoded small RNA; EBNA, EBV nuclear antigen; EBNA‐LP, EBV nuclear antigen leader protein.
In this review, we tentatively categorized in latency type II.
a
Expression of latent membrane protein 1 (LMP1) in gastric cancer and EBV latency of gastric cancer is controversial.