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Seasonal influenza H1 and B but not seasonal H3 cause disease in mice. Mice were infected with increasing doses of different influenza viruses intranasally in 100 μl volumes. Weight loss was measured after infection with A/England/195/2009 (A), A/Puerto Rico/8/1934 (B), A/England/691/2010 (C), A/X-31 (D), B/Florida/04/06 (Yamagata) (E) or B/Brisbane/60/2008 (Victoria) (F). Points represent mean of n ≥ 4 animals ± SEM.
