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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Nov 6;47:138–145. doi: 10.1016/j.conb.2017.10.002

Figure 2. Microglial cytokine signaling regulates functional synapse plasticity.

Figure 2

(a) Summary of microglial-derived TNFα effects on AMPA receptor (red) internalization within the nucleus accumbens following cocaine administration. (b) Summary CX3CL1 and IL-1β effects on LTP. Red receptors represent membrane-associated postsynaptic AMPA receptors necessary for LTP. Note the differing results assessing LTP in Cx3cr1−/− (Maggi et al., 2009, top vs. Rogers et al., 2011, bottom).