Table 3.

Crude and adjusted hazard ratios for death during first 2-years of MDR TB treatment in three provinces, South Africa, 2005–2008.

		Bivariate Modelsa			Multivariable Modelb (N=372)
Factor		N	HR	(95% CI)	aHR	(95% CI)
HIV Status	HIV+ vs. HIV−	395	2.20	(1.22 3.97)	2.28	(1.11 4.68)
Sex	Male vs. Female	394	3.01	(1.73 5.24)	2.69	(1.47 4.91)
Age	>7 years vs. ≤7 years	395	0.55	(0.33 0.93)	0.56	(0.29 1.06)
Resistance Type	PreXDR/XDR TB vs. MDRc TB	345	1.55	(0.81 2.97)	Not included
Weight Status	Underweightd vs. normal	372	2.59	(1.37 4.87)	2.65	(1.37 5.13)
Culture+ > 6mose	Yes vs. No	395	1.24	(0.70 2.18)	Not included

Abbreviations: MDR, multidrug resistant; TB, tuberculosis; HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval; HIV, human immunodeficiency virus; XDR, extensively drug resistant; mos, months.

^aBivariate Cox proportional hazard models.

^bMultivariable Cox proportional hazard model, stratified on province and year of diagnosis.

^cIncludes rifampicin mono-resistance.

^dWeight for age adjusted Z-score >2 standard deviations below the mean.

^eAny positive culture results 6 months or after start of first DR TB treatment regimen.