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. 2018 Feb 5;131(3):323–329. doi: 10.4103/0366-6999.223840

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Copyright: © 2018 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Antivenom with HBO significantly reduced serum MDA and increased serum SOD levels at 1 h after injection of the snake venom. (a) Serum SOD level lightly increased after injection of the snake venom and the phenomenon could be improved by the antivenom, which was more significant with the administration of antivenom + HBO especially within 5 h after envenomation. (b) The serum MDA level after envenomation. It showed the completely opposite tendency compared with the serum SOD levels. The antivenom with HBO administration showed more significant antioxidant effects within 5 h. Values (mean ± standard deviation) are representative of six independent experiments (n = 6 mice/group). *P < 0.05: Compared with control group; ^†P < 0.05: Compared with the snake venom at the same time point; ^‡P < 0.05: Compared with the antivenom group; HBO: Hyperbaric oxygen; MDA: Malondialdehyde; SOD: Superoxide dismutase.