Table 3.
Univariable competing risk regression models of 3-year recurrence risk. Results were estimated with univariable Fine & Gray competing risk regression models, treating death-from-any-cause as the competing event of interest. Abbreviations: SHR – Subdistribution hazard ratio, 95%CI – 95% confidence interval, BMI – Body mass index, ECOG – Eastern Cooperative Oncology Group, L1 – Lymphatic invasion, V1 – Vascular invasion, MSI – Microsatellite instability status, UICC – Union Internationale pour le lutte contre le cancer TLS/mm – TLS count, ECOG – Eastern Cooperative Oncology Group, % E-TLS – Proportion of Early tertiary lymphoid structure (TLS), Q1 – 25th percentile of the variable's distribution (i.e. quartile 1 (Q1)), % PFL-TLS – Proportion of primary follicle-like TLS, % SFL-TLS – Proportion of secondary follicle-like TLS, GC – Germinal center, EB – Empirical Bayes, ITIS – Integrated TLS ImmunoScore, CART – Classification and Regression Tree, G/L – 109/liter.
| Variable |
SHR |
95%CI |
p |
|---|---|---|---|
| Demographic variables | |||
| Female sex | 0.58 | 0.22–1.57 | 0.283 |
| BMI (per 5 kg/m2 increase) | 0.57 | 0.29–1.12 | 0.105 |
| Age at study entry ≥ 75 years | 3.97 | 1.54–10.21 | 0.004 |
| Smoking | 0.92 | 0.20–4.24 | 0.916 |
| ECOG performance status > 0 | 7.85 | 2.54–24.28 | <0.0001 |
| Tumor variables | |||
| Right sided tumor | 1.14 | 0.42–3.08 | 0.794 |
| L1 | 1.38 | 0.47–4.01 | 0.554 |
| V1 | 1.08 | 0.23–5.13 | 0.925 |
| MSI high | 0.54 | 0.07–3.90 | 0.538 |
| B-RAF V600E mutant | 0.54 | 0.08–3.67 | 0.532 |
| Tumor grade G3 | 2.14 | 0.80–5.76 | 0.130 |
| UICC tumor stage III | 2.02 | 0.65–6.25 | 0.222 |
| Adjuvant chemotherapy | 1.23 | 0.42–3.59 | 0.710 |
| Immune contexture variables | |||
| TLS/mm ≤ Q1 | 2.24 | 0.84–5.92 | 0.106 |
| % E-TLS ≥ Q3 | 2.21 | 0.85–5.77 | 0.104 |
| % PFL-TLS ≤ Q1 | 2.24 | 0.83–6.06 | 0.111 |
| % SFL-TLS ≤ Q1 | 3.73 | 1.39–10.00 | 0.009 |
| ≥1GC-harboring TLS | 0.30 | 0.11–0.79 | 0.015 |
| Immune_context EB prediction(per 1 unit increase) | 0.54 | 0.34–0.86 | 0.010 |
| ITIS (per 10 units increase) | 0.73 | 0.55–0.95 | 0.020 |
| ITIS ≤ CART cut-off | 4.83 | 1.82–12.85 | 0.002 |
| Laboratory parameters | |||
| Absolute leukocyte count (per 1 G/L increase) | 0.91 | 0.78–1.07 | 0.264 |
| Absolute platelet count (per 50 G/L increase) | 0.79 | 0.62–1.00 | 0.052 |
| Absolute neutrophil count (per 1 G/L increase) | 0.94 | 0.81–1.08 | 0.368 |
| Absolute lymphocyte count (per 1 G/L increase) | 0.41 | 0.19–0.86 | 0.019 |
| Neutrophil-lymphocyte-ratio (per 5 units increase) | 1.00 | 0.73–1.35 | 0.975 |