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. Author manuscript; available in PMC: 2018 Dec 9.

Published in final edited form as: Lancet. 2017 Sep 8;390(10112):2569–2582. doi: 10.1016/S0140-6736(17)31610-0

Rank and Contribution to Cumulative Burden of Condition-specific Outcomes among SJLIFE Childhood Cancer Survivors and Community-Controls by Diagnosis Group at 50 Years of Age. Panels A and B present the ranking and absolute cumulative burden for the grade 1–5 and grade 3–5 condition-specific outcomes, respectively.

Condition-specific outcomes (detailed composition in the supplement, pages 5–9) are rank ordered in the first portion of figure (reds and greens) according to the top 20 community-control cumulative burden. All condition-specific outcomes ranked below the top 20 among community-controls but within the top 10 among any primary cancer subgroup were also included. In the second portion of the figure (blues), each box corresponds to absolute cumulative burden count per person for each condition-specific outcome and cohort subgroup. For example, ocular disorders rank 14^th in terms of absolute grade 3–5 cumulative burden per individual among controls with, on average, 1 occurrence of a severe or life-threatening ocular condition among 25 persons (0.04 cumulative burden per individual). Among AML survivors, ocular disorders rank as the 9^th largest absolute cumulative burden with, on average, 1 occurrence of a grade 3–5 condition among 4 survivors (0.23 cumulative burden per survivor). Colors represent overall percentiles per the legend on right. ALL: Acute Lymphoblastic Leukemia; AML: Acute Myeloid Leukemia; NHL: Non-Hodgkin Lymphoma; CNS: Central Nervous System Malignancies; Bone-Tumor: Osteosarcoma and Ewing Sarcoma; Soft-Tissue: Soft-Tissue Sarcomas.

Rank and Contribution to Cumulative Burden of Condition-specific Outcomes among SJLIFE Childhood Cancer Survivors and Community-Controls by Diagnosis Group at 50 Years of Age. Panels A and B present the ranking and absolute cumulative burden for the grade 1–5 and grade 3–5 condition-specific outcomes, respectively.

Condition-specific outcomes (detailed composition in the supplement, pages 5–9) are rank ordered in the first portion of figure (reds and greens) according to the top 20 community-control cumulative burden. All condition-specific outcomes ranked below the top 20 among community-controls but within the top 10 among any primary cancer subgroup were also included. In the second portion of the figure (blues), each box corresponds to absolute cumulative burden count per person for each condition-specific outcome and cohort subgroup. For example, ocular disorders rank 14^th in terms of absolute grade 3–5 cumulative burden per individual among controls with, on average, 1 occurrence of a severe or life-threatening ocular condition among 25 persons (0.04 cumulative burden per individual). Among AML survivors, ocular disorders rank as the 9^th largest absolute cumulative burden with, on average, 1 occurrence of a grade 3–5 condition among 4 survivors (0.23 cumulative burden per survivor). Colors represent overall percentiles per the legend on right. ALL: Acute Lymphoblastic Leukemia; AML: Acute Myeloid Leukemia; NHL: Non-Hodgkin Lymphoma; CNS: Central Nervous System Malignancies; Bone-Tumor: Osteosarcoma and Ewing Sarcoma; Soft-Tissue: Soft-Tissue Sarcomas.