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. Author manuscript; available in PMC: 2018 Feb 5.
Published in final edited form as: J Urol. 2013 Sep 11;191(3):823–829. doi: 10.1016/j.juro.2013.09.012

Figure 1. Effect of BCG viability on iNOS mRNA Expression and NO production.

Figure 1

Exposure of UC cells to viable BCG increased the expression of iNOS mRNA 8.8- and 4.6-fold in 253J and T24 cells, respectively. This increase was reduced to 5.8- and 3.3-fold in response to hk BCG. The difference in iNOS induction between viable and hkBCG was not statistically significant (p = 0.15).

Exposure of UC cells to BCG significantly increased NO production in both cell lines (p < 0.05). Relative to controls, BCG treatment significantly increased NO levels in both T24 (p < 0.0001) and 253J cell lines (p < 0.05). Treatment with hk BCG significantly increased NO levels in T24 p < 0.05) but not in 253J p= 0.4). The difference in NO production between hk BCG and BCG was statistically significant (p < 0.05).