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Examples of adjuvant mechanisms of action and discovery: (A) inhibition of antibiotic modification; (B) inhibition of target modification; (C) inhibition of efflux; (D) enhancement of antibiotic uptake; (E) inhibition of signaling pathways that mediate antibiotic resistance; (F) inhibition of biofilm formation, which leads to increased antibiotic tolerance; (G) target-blind whole cell screening of previously approved drugs for adjuvant activity.
