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. Author manuscript; available in PMC: 2018 Feb 5.

Published in final edited form as: Mol Genet Metab. 2017 Jun 3;122(1-2):92–99. doi: 10.1016/j.ymgme.2017.06.001

Fig. 2 — Neutralizing antibodies and urinary GAG. Neutralizing antibodies were measured by two methods, percent inhibition of enzyme activity by neutralizing antibodies (NAb% inhibition) and neutralizing antibody titers. The method used to measure neutralizing antibodies depended on the number of months since non-immunosuppressive and non-cytotoxic immune tolerance (NICIT) regimen was started. Month 0 is the month that NICIT regimen was started. Quantitative urinary GAG was measured using DMB assay and CPC assay throughout the study. A) Neutralizing antibodies measured as percent inhibition of enzyme activity by neutralizing antibodies (NAb % inhibition) on month −11 to month 25 since NICIT regimen was started. The left y-axis depicts neutralizing antibodies. The right y-axis depicts quantitative urinary GAG. B) Neutralizing antibodies measured as neutralizing antibody titers on month 26 to month 59 since NICIT regimen was started. The left y-axis depicts neutralizing antibodies. The right y-axis depicts quantitative urinary GAG.

Fig. 2 — Neutralizing antibodies and urinary GAG. Neutralizing antibodies were measured by two methods, percent inhibition of enzyme activity by neutralizing antibodies (NAb% inhibition) and neutralizing antibody titers. The method used to measure neutralizing antibodies depended on the number of months since non-immunosuppressive and non-cytotoxic immune tolerance (NICIT) regimen was started. Month 0 is the month that NICIT regimen was started. Quantitative urinary GAG was measured using DMB assay and CPC assay throughout the study. A) Neutralizing antibodies measured as percent inhibition of enzyme activity by neutralizing antibodies (NAb % inhibition) on month −11 to month 25 since NICIT regimen was started. The left y-axis depicts neutralizing antibodies. The right y-axis depicts quantitative urinary GAG. B) Neutralizing antibodies measured as neutralizing antibody titers on month 26 to month 59 since NICIT regimen was started. The left y-axis depicts neutralizing antibodies. The right y-axis depicts quantitative urinary GAG.