Table 3.
Terminal residues bordering the PC cleavage site connectivity region and distances in the dimer structures
| Structure | Prodomain C terminus | Growth factor N terminus | Terminal residues in each chain | Missing residues | Distance |
|---|---|---|---|---|---|
| Å | |||||
| Pro-TGF-β1 R249A mutant (5VQP) | Chain A, Leu-242 | Chain A, Leu-251 | A, Leu-242; A, Leu-251 | 8 | 18 |
| A, Leu-242; Syma/Leu-251 | 8 | 32 | |||
| Pro-TGF-β1 dimer (G+H) in complex with integrin (5FFO) | Chain G, Gln-240 | Chain G, Ala-250 | G, Gln-240; G, Ala-250 | 9 | 20 |
| G, Gln-240; H, Ser-259 | 18 | 46 | |||
| Chain H, Gln-240 | Chain H, Ser-259 | H, Gln-240; H, Ser-259 | 18 | 23 | |
| H, Gln-240; G, Ala-250 | 9 | 39 | |||
| Pro-TGF-β1 dimer (C+D) in complex with integrin (5FFO) | Chain C, Gln-240 | Chain C, Ala-250 | C, Gln-240; C, Ala-250 | 9 | 21 |
| C, Gln-240; D, Cys-256 | 15 | 47 | |||
| Chain D, Gln-240 | Chain D, Cys-256 | D, Gln-240; D, Cys-256 | 15 | 20 | |
| D, Gln-240; C, Ala-250 | 9 | 39 |
a Symmetry-related molecule.