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ST6Gal-I promotes TNFR1-mediated survival signaling. A and B, MiaPaCa-2 EV and KD (A) and OV4 EV and OE cells (B) were treated with TNF for 6 and 24 h and immunoblotted for p-Akt, pNF-κB–p65, and cIAP2. C, OV4 EV or OE cells were cultured with or without an anti-TNFR1 neutralizing antibody for 24 h, and lysates were immunoblotted for p-Akt, pNF-κB–p65, and cIAP2.
