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A schematic model that illustrates a possible role of the TFIIBc-Ssu72 complex in pol II transcription reinitiation. A “hand-off” model may explain the conceivable role of Ssu72 in pol II reinitiation by modulating TFIIB conformation, in a manner similar to the archetypal acidic activator VP16. Arrows, relative orientations of the cyclin domains of TFIIBc. Ssu72 may further maintain the relative orientation of the two cyclin-like domains in an active conformation.
