Figure 3.

VDAC3-KO mice fail to regulate ENaC channel activity in response to dietary salt challenge. Wildtype and VDAC3-KO mice were fed with low-salt, normal-salt, or high-salt diets. After 2 weeks, mice were sacrificed by cervical dislocation and renal tubules were manually dissected. ENaC activity was recorded from cell-attached patches on principal cells as previously described (3, 12). A, representative traces from wildtype and VDAC3-KO mice on different diets. B, summary of the open probability from wildtype and VDAC3-KO mice on different diets, presented as scatter plot with standard deviation. p values were marked as above, one-way ANOVA with Holm-Sidak post test.