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. 2017 Dec 13;293(5):1756–1766. doi: 10.1074/jbc.M117.807859

Figure 5.

Figure 5.

Multiple sequence alignment of rodent and human ASIC3 protein including species closely related to naked mole-rat or living in similarly hypoxic/hypercapnic habitats. A, amino acids 1–10, methionine is missing in the naked mole-rat (arrow). B, amino acids 55–69, change of alanine 62 to glutamate in naked mole-rat (arrow). C, amino acids 99–112, change of arginine to histidine in naked mole-rat and Damaraland mole-rat (arrow). D, pH-response curves of mASIC3 and mASIC3-ATG. E, pH-response curves of rASIC3, rASIC3-A62E, rASIC3-A62E/R102H. Data were analyzed by a t test.