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Location of residues targeted for deep mutational scan of the T1 TCR. Crystal structure of Mel5 TCR (with Vβ domain in blue and Vα domain in red) in complex with MART-1 (green)·HLA-A2 (gray) (PDB code 3HG1) is shown. Regions in which residues of the T1 TCR were subjected to deep mutational scanning are labeled. CDR, complementarity-determining region; FR, framework region.
