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. 2018 Jan 16;115(5):E886–E895. doi: 10.1073/pnas.1712952115

Fig. 4.

Fig. 4.

Stapled peptides selectively depolarize mitochondria in Mcl-1–dependent cancer cells as assayed by BH3 profiling. (A) Percent mitochondrial membrane depolarization in permeabilized H929 or O-Mcl-1 cells treated with SAH-MS1 peptides. Data are mean ± SD for at least three independent measurements. (B) EC50 values (peptide concentration in M) for mitochondrial membrane depolarization induced by SAH-MS1-14 and SAH-MS1-18 peptides in the indicated cell lines (Mcl-1–dependent cell line data highlighted in green).