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Crystal structure of the GDF8 prodomain complex. The GDF8 prodomain complex containing the mature dimer (gray and pale green), alpha-1 helix (blue), latency lasso (cyan), and fastener (magenta). (Middle Inset) Depiction of the alpha-1 helix and fastener regions following a 75° rotation about the y axis (Middle) Note the location of residues I53, I56, I60, and I64 within the alpha-1 helix and Y111 and H112 within the fastener regions. See also Fig. S4.
