KEGG pathways: proteosome (A), spliceosome (B), ribosomal proteins (C), phototransduction and odorant receptors (D), pyruvate metabolism (E), and purine metabolism (F). Axes are as in Fig. 2: DGE on the horizontal axis is associated with direct selection on biting, and DGE on the vertical axis is associated with the evolutionary transition from blood feeding to obligate nonbiting. The lower left quadrant plots DGE associated with blood feeding; the upper right quadrant plots genes associated with nonbiting.