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Structure and biosynthesis of capuramycin-type metabolites. Proposed biosynthesis of the shared CarU core of capuramycin-type metabolites A-500359s and A-503083s starting from UMP. CapA and CapH, along with the homologs LipL and LipK from the biosynthetic pathway for A-90289 that contains an intact (5′S,6′S)-GlyU in the final metabolite, have been previously assigned in vitro. *LipK was previously shown to stereospecifically generate (5′S,6′S)-GlyU. αKG, α-ketoglutarate.
