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Proposed model for regulation of S6 phosphorylation (P) by the cAMP/PKA pathway. PKA, after activation by cAMP, regulates P of S6 via two different routes. One, involving the mTORC1/P70/S6 pathway, is inhibited by sirolimus, and the other, bypassing mTOR, involves P of S6 by PKA. R, regulatory subunit.
