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Schematic representing the longitudinal infection experiments performed with P. knowlesi in rhesus monkeys, demonstrating the phenomenon of malaria antigenic variation, and reported by K.N. Brown and I.N. Brown in 1965, in Nature (Brown and Brown, 1965). Different VSAs are expressed in the course of an infection, as antigenic variation occurs in response to the appearance of anti-VSA antibody (ab). VSA, variable surface antigens.
