Large parasite-encoded proteins |
✓ |
✓ |
Exposed at infected RBC surface |
✓ |
✓ |
Extractable only by ionic detergents |
✓ |
✓ |
Undergo antigenic variation |
✓ |
✓ |
Associated with virulence |
✓ |
✓ |
Encoded by large multigene family |
✓ |
✓ |
Contain cysteine-rich domains |
✓ |
✓ |
Subject to much diversity |
✓ |
✓ |
Genes on all chromosomes |
✓ |
✓ |
In situ transcription |
✓ |
✓ |
Abundant transcription in ring stage |
✓ |
✓ |
Translation in trophozoite stage |
✓ |
✓ |
Antisense long non-coding RNAs in gene regulation |
✓ |
✓ |
Epigenetic gene control |
✓ |
✓ |
Role for spleen in expression control |
✓ |
✓ |
Associated with typical cytoadherence/sequestration |
×
a
|
✓ |