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. Author manuscript; available in PMC: 2018 Dec 4.
Published in final edited form as: Neuroscience. 2017 Sep 23;365:23–32. doi: 10.1016/j.neuroscience.2017.09.034

Figure 8. Diagram summarizing the mechanism proposed for BK on nucleus ambiguus neurons.

Figure 8

BK, acting on B2 receptors (B2R) of nAmb increases [Ca2+]i by promoting Ca2+ influx via P/Q voltage-gated Ca2+ channels (VGCC) at the plasma membrane, and Ca2+ release from endoplasmic reticulum, via IP3 receptor (IP3R) and ryanodine receptor (RyR). BK also depolarizes Amb neurons, leading to acetylcholine release to the cardiac ganglia and subsequent bradycardia.