Table 2.
Comorbidities in patients with atrial fibrillation before and after dementia diagnosis
| Atrial fibrillation (N = 8,096) | No treatment (n = 2,978; 37%) | Warfarin (n = 2,143; 27%) | p-value for dif. to no treatment | Antiplatelets (n = 2,975; 37%) | p-value for dif. to warfarin |
| Number of drugs, med (IQR) | 5.0 (23) | 6.0 (21) | <0.001 | 6.0 (23) | <0.001 |
| Comorbidities at dementia diagnosis | |||||
| Diabetes mellitus, n (%) | 520 (17.5) | 460 (21.5) | <0.001 | 596 (20.0) | 0.212 |
| Hypertension, n (%) | 1817 (61.0) | 1400 (65.3) | 0.002 | 1908 (64.1) | 0.378 |
| Liver disease, n (%) | 50 (1.7) | 20 (0.9) | 0.023 | 34 (1.1) | 0.469 |
| Kidney disease, n (%) | 334 (11.2) | 179 (8.4) | 0.001 | 327 (11.0) | 0.002 |
| Heart failure, n (%) | 1062 (35.7) | 841 (39.2) | 0.009 | 1100 (37.0) | 0.099 |
| Pacemaker, n (%) | 388 (13) | 351 (16.4) | 0.001 | 291 (9.8) | <0.001 |
| Previous ischemic heart disease, n (%) | 985 (33.1) | 750 (35.0) | 0.152 | 1202 (40.4) | <0.001 |
| Previous all stroke, n (%) | 659 (22.4) | 503 (23.5) | 0.258 | 704 (23.7) | 0.873 |
| Previous ischemic stroke, n (%) | 494 (16.6) | 432 (20.2) | 0.001 | 533 (17.9) | 0.043 |
| Previous nontraumatic intracranial hemorrhage, n (%) | 116 (3.9) | 23 (1.1) | <0.001 | 97 (3.3) | <0.001 |
| Previous traumatic intracranial hemorrhage, n (%) | 81 (2.7) | 22 (1.0) | <0.001 | 65 (2.2) | 0.002 |
| Previous any hemorrhage, n (%) | 571 (19.2) | 284 (13.3) | <0.001 | 467 (15.7) | 0.015 |
| Outcomes after dementia diagnosis | |||||
| All stroke, n (%) | 243 (8.2) | 176 (8.2) | 0.946 | 338 (11.4) | <0.001 |
| Ischemic stroke, n (%) | 180 (6.0) | 111 (5.2) | 0.187 | 260 (8.7) | <0.001 |
| Nontraumatic intracranial hemorrhage, n (%) | 40 (1.3) | 40 (1.9) | 0.136 | 49 (1.6) | 0.553 |
| Traumaticintracranial hemorrhage, n (%) | 32 (1.1) | 23 (1.1) | 0.996 | 35 (1.2) | 0.731 |
| Any hemorrhage, n (%) | 199 (6.7) | 160 (7.5) | 0.278 | 205 (6.9) | 0.430 |
| Death, n (%) | 1105 (37.1) | 600 (28.0) | <0.001 | 1389 (46.7) | <0.001 |
AF, atrial fibrillation, N (%), number of patients in each category and percentage relative to the whole cohort, IQR, interquartile range. For number of drugs there were 339 (4.2%) missing.