Table 1.
Demographics and biomarkers, HCB and ADNI separately, and for HCB and ADNI merged together
| HCB | ADNI | HCB+ADNI | ||||||||||
| NC | Pre | MCI | AD | NC | Pre | MCI | AD | NC | Pre | MCI | AD | |
| N | 40 | 12 | 21 | 14 | 28 | 16 | 23 | 29 | 68 | 28 | 44 | 43 |
| Women/Men | 26/14 | 7/5 | 10/11 | 8/6 | 15/13 | 10/6 | 7/16 | 11/18 | 41/27 | 17/11 | 17/27 | 19/24 |
| Mean Age | 62.1 | 72.7* | 70* | 65.9† | 71.8‡ | 75.8* | 72.4 | 74.2‡ | 66.1 | 74.5* | 71.3* | 71.5* |
| SD | 8.5 | 6 | 7.5 | 9 | 5.1 | 4.6 | 8 | 7.8 | 8.7 | 5.5 | 7.9 | 9.1 |
| Mean education (y) | 11.9 | 10.6 | 11 | 8.6* | 17.2‡ | 16.2‡ | 16.1‡ | 15.2* | 14.1 | 13.8 | 13.7 | 13 |
| SD | 4.4 | 4 | 4.3 | 4.2 | 2.6 | 2.1 | 2.8 | 2.8 | 4.6 | 4.2 | 4.4 | 4.5 |
| APOE ɛ4 carrier | 9 | 4 | 10 | 8 | 7 | 8 | 21 | 20 | 16 | 12 | 31 | 28 |
| Non-carrier | 31 | 8 | 10 | 6 | 21 | 8 | 2 | 9 | 52 | 16 | 12 | 15 |
| Mean Aβ | 760.8 | 375.8 | 339.1 | 310.7 | 239 | 148.5 | 135.7 | 130 | ||||
| SD | 160.3 | 80.1 | 71.9 | 83.9 | 25.7 | 24.1 | 20.7 | 23.1 | ||||
| Mean p-tau | 56.6 | 76.6 | 112.2 | 105.7 | 31.2 | 51.7 | 52.9 | 66.6 | ||||
| SD | 27.7 | 47.8 | 43.7 | 43 | 12.2 | 32.9 | 18.7 | 43 | ||||
*Significantly different versus Control group (p < 0.05); †Significantly different versus Preclinical group (p < 0.05); ‡Significantly different versus same group in HCB population (p < 0.05). NC, normal controls; Pre, preclinical; MCI, mild cognitive impairment due to AD; AD, Alzheimer’s disease patients.