Fig. 2.

Effect of FTO-R313A on body composition.

A,B. Absolute and relative fat and lean mass in female and male homozygous FTO-R313A mice (R313A/R313A) and littermate controls (wt/wt) measured by Echo-MRI at 9 (A) and 17 (B) weeks of age. C. Relative fat and lean mass in male and female mice at 20 weeks of age, measured by Dual-energy X-ray absorptiometry (DEXA). D. Post-mortem weights of visceral and sub-cutaneous white adipose tissue (WAT). Males: wt/wt (A,Bn = 7; Cn = 11; Dn = 3), R313A/R313A (A,Bn = 7; Cn = 11; Dn = 3). Females: wt/wt (A,Bn = 13; Cn = 16; Dn = 9), R313A/R313A (A,Bn = 13; Cn = 17; Dn = 7). Data points indicate individual animals, horizontal bars denote mean ± SEM.