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. 2018 Mar;1864(3):843–850. doi: 10.1016/j.bbadis.2017.11.027

Fig. 5.

Fig. 5

Effect of FTO on bone density and mineral content.

A,B. Bone mineral density (A) and bone mineral content (B) of 20 week homozygous FTO-R313A mice (R313A/R313A, n = 17(f), n = 11(m)) and littermate controls (wt/wt, n = 16(f), n = 11(m)), measured by DEXA.

C,D. Bone mineral density (C) and bone mineral content (D) of homozygous FTO knockout mice (ko/ko, n = 30(f), n = 32(m)), littermate heterozygous FTO knockout mice (wt/ko, n = 19(f), n = 17(m)) and littermate controls (wt/wt, n = 7(f), n = 8(m)) for both genders at 24 weeks of age.

E,F. Bone mineral density (E) and bone mineral content (F) of male homozygous FTO-I367F mice (I367F/I367F, n = 15) and littermate controls (wt/wt, n = 14) at 24 weeks of age.

Bone mineral density values in A, C and E were adjusted for body mass by multiple linear regression. Data points indicate individual animals, horizontal bars mean ± SEM.