Table 3.
RHC-derived hemodynamic parameters.
| Baseline (n = 100) | Week 16 (n = 100) | Mean change from baseline (SD) (n = 100) | P value | |
|---|---|---|---|---|
| Mean mRAP, mmHg (SD) | n = 99 9.7 (5.73) | n = 92 9.3 (6.70) | n = 91 −0.3 (7.03) | 0.733 |
| Mean mPAP, mmHg (SD) | n = 100 46.1 (14.04) | n = 92 41.5 (14.09) | n = 92 −4.3 (9.09) | <0.001 |
| Mean PVR, Wood units (SD) | n = 99 9.8 (5.73) | n = 89 7.4 (4.73) | n = 88 −2.1 (2.94) | <0.001 |
| Mean PVR index, WU/m2 (SD) | n = 98 5.5 (3.43) | n = 88 4.2 (2.86) | n = 87 −1.2 (1.70) | <0.001 |
| Mean SV:PP, (L/min)/(bpm/mmHg) (SD) | n = 95 1.5 (0.74) | n = 90 1.6 (0.78) | n = 85 0.2 (0.93) | 0.096 |
| Mean SVR:PVR (SD) | n = 97 2.7 (1.44) | n = 89 3.6 (3.78) | n = 86 0.8 (3.30) | 0.02 |
| Mean SVO2, % (SD) | n = 85 62.9 (9.02) | n = 78 65.1 (11.12) | n = 75 2.4 (9.54) | 0.03 |
| Mean cardiac output, L/min (SD) | n = 100 4.3 (1.42) | n = 91 4.6 (1.43) | n = 91 0.4 (0.98) | <0.001 |
| Mean cardiac index, L/min/m2 (SD) | n = 99 2.3 (0.69) | n = 90 2.5 (0.67) | n = 90 0.2 (0.54) | <0.001 |
mPAP, mean pulmonary artery pressure; mRAP, mean right artery pressure; PP, pulse pressure; PVR, pulmonary vascular resistance; SD, standard deviation; SV, stroke volume; SVO2, mixed venous oxygen saturation; SVR, systemic vascular resistance.