Table 1.
Echocardiographic function variables.
| Variables | Control group (n = 8) |
P value | PAH group (n = 11) |
P value | ||
|---|---|---|---|---|---|---|
| Baseline | LPS-treated | Baseline | LPS-treated | |||
| LVSV (mL) | 0.448 ± 0.142 | 0.382 ± 0.110 | 0.069 | 0.251 ± 0.093 | 0.175 ± 0.054 | 0.043 |
| HR (bpm) | 424 ± 38 | 418 ± 13 | 0.650 | 390 ± 37 | 334 ± 55 | 0.001 |
| CO (L/min) | 0.191 ± 0.059 | 0.164 ± 0.049 | 0.087 | 0.101 ± 0.032 | 0.058 ± 0.020 | 0.001 |
| RVEDD (mm) | 2.960 ± 0.163 | 3.167 ± 0.195 | 0.004 | 4.873 ± 0.287 | 5.509 ± 0.422 | 0.000 |
| TAPSE (mm) | 3.12 ± 0.24 | 2.57 ± 0.31 | 0.001 | 2.25 ± 0.28 | 1.58 ± 0.24 | 0.000 |
| sPAP (mmHg) | 74.5 ± 9.1 | 95.4 ± 13.8 | 0.001 | |||
| Strain % | ||||||
| Basal RV free wall | −19.41 ± 4.77 | −15.5 ± 3.21 | 0.059 | −12.18 ± 3.33 | −7.54 ± 3.47 | 0.000 |
| Mid RV free wall | −17.19 ± 4.98 | −13.18 ± 2.71 | 0.057 | −11.45 ± 4.74 | −7.23 ± 2.94 | 0.000 |
| Strain rate I/S | ||||||
| Basal RV free wall | −4.35 ± 1.00 | −3.69 ± 1.48 | 0.331 | −4.12 ± 1.32 | −2.66 ± 1.12 | 0.001 |
| Mid RV free wall | −3.97 ± 1.27 | −3.20 ± 0.61 | 0.068 | −3.52 ± 1.43 | −2.56 ± 1.07 | 0.014 |
Values are mean ± SD.
LV SV, LV stroke volume; HR, heart rate; CO, cardiac output; RVEDD, RV end-diastolic diameter; TAPSE, tricuspid annular plane systolic excursion; sPAP, pulmonary artery systolic pressure.