Fig. 1.
Macitentan treatment reduces hemodynamic indices of PAH in HFD-fed ApoE−/− mice. Bar graphs show (a) pulmonary artery acceleration time (PA-AT), (b) RV systolic pressure (RVSP), (c) RV arterial elastane (RVEa), (d) RV dP/dtmax in mm Hg/s, (e) cardiac output, (f) mean aortic pressure (mAoP), (g) LV end-diastolic pressure (LVeDP). (a, f) Measures were made using Vevo 770 echocardiography v3.0. All other measures were made using closed chest cardiac pressure volume catheterization. Bars represent mean ± SEM, n = 6–20, individual animals represented by dots. (a–g) Statistical differences between chow-fed ApoE−/−, HFD-fed, and HFD-fed + macitentan were assessed by Kruskal–Wallis analysis of variance with Dunn’s multiple comparison post-hoc test; *P < 0.05, **P < 0.01.