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. 2018 Feb 5;13(2):e0192498. doi: 10.1371/journal.pone.0192498

Fig 3. In vitro, sevoflurane and MLA clearly decreased the dendritic spine density and length, and PNU reversed this effect.

Fig 3

Golgi-Cox staining was performed for the dendritic spine density and length in stratum radiaum neurons of CA1 area in 7-day-old rat brain slices (A). Sevoflurane induced significant decreases in dendritic spine density and length. n = 8 for each group; compared with group C, *P < 0.01, ANOVA. PNU-282987 prevented changes in dendritic spine density and length. n = 8 for each group; compared with group S, #P < 0.01, ANOVA. PNU-282987 increased the dendritic spine density and length, but MLA induced significant decreases in dendritic spine density and length. n = 8 for each group; compared with group C, *P < 0.01, ANOVA (B and C).