TABLE 3.
Lipid class | h2 (P-value) | β (P-value) | ERV | Clinical covariates included* |
---|---|---|---|---|
PI | 0.26 (6.71×10−05) | −1.18 (2.10−03) | 0.49 | Any alcohol use disorder; diabetes status |
LPE | 0.19 (7.82×10−03) | −0.83 (0.03) | 0.33 | None |
LPC | 0.32 (3.10×10−11) | −0.70 (0.06) | 0.27 | None |
PC(O) | 0.40 (4.34×10−15) | 0.54 (0.08) | 0.20 | Any anxiety disorder; any depressive disorder |
PE | 0.41 (8.69×10−14) | −0.43 (0.24) | 0.17 | Diabetes status |
PC(P) | 0.32 (1.58×10−04) | 0.48 (0.21) | 0.19 | Any anxiety disorder |
PG | 0.38 (1.20×10−14) | −0.24 (0.12) | 0.18 | Diabetes status; any alcohol use disorder |
LPC(O) | 0.52 (1.84×10−10) | 0.57 (0.70) | 0.18 | Diabetes status; BMI |
PC | 0.28 (3.00×10−11) | −0.24 (0.17) | 0.10 | Any alcohol use disorder; diabetes status; BMI |
PS | 0.34 (1.01×10−14) | 0.21 (0.54) | 0.08 | Any substance use disorder; hypertension; smoker; BMI |
SM | 0.38 (1.17×10−14) | 0.19 (0.94) | 0.08 | Smoker; any alcohol use disorder; any substance use disorder; any anxiety disorder |
PE(O) | 0.38 (2.50×10−06) | 0.16 (0.71) | 0.06 | Any depressive disorder |
PE(P) | 0.45 (6.96×10−09) | 0.16 (0.70) | 0.06 | Any anxiety disorder; any depressive disorder |
Bold indicates class surviving multiple testing correction.
BMI, body mass index; ERV, endophenotype ranking value; PI, phosphatidylcholine; LPE, lysophosphatidylethanolamine; LPC, lysophosphatidylcholine; PC(O), alkylphosphatidylcholine; PE, phosphatidylethanolamine; PC(P), alkenylphosphatidylcholine; PG, phosphatidylglycerol; LPC(O), lysoalkylphosphatidylcholine; PC, phosphatidylcholine; PS, phosphatidylserine; SM, sphingomyelin; PE(O), alkylphosphatidylethanolamine; PE(P), alkenylphosphatidylethanolamine.
Threshold of P<.1.