Skip to main content
. Author manuscript; available in PMC: 2018 Feb 5.
Published in final edited form as: Bipolar Disord. 2017 Feb 23;19(2):107–115. doi: 10.1111/bdi.12468

TABLE 3.

Heritability and degree of bipolar relatedness for all lipid classes

Lipid class h2 (P-value) β (P-value) ERV Clinical covariates included*
PI 0.26 (6.71×1005) 1.18 (2.1003) 0.49 Any alcohol use disorder; diabetes status
LPE 0.19 (7.82×10−03) −0.83 (0.03) 0.33 None
LPC 0.32 (3.10×10−11) −0.70 (0.06) 0.27 None
PC(O) 0.40 (4.34×10−15) 0.54 (0.08) 0.20 Any anxiety disorder; any depressive disorder
PE 0.41 (8.69×10−14) −0.43 (0.24) 0.17 Diabetes status
PC(P) 0.32 (1.58×10−04) 0.48 (0.21) 0.19 Any anxiety disorder
PG 0.38 (1.20×10−14) −0.24 (0.12) 0.18 Diabetes status; any alcohol use disorder
LPC(O) 0.52 (1.84×10−10) 0.57 (0.70) 0.18 Diabetes status; BMI
PC 0.28 (3.00×10−11) −0.24 (0.17) 0.10 Any alcohol use disorder; diabetes status; BMI
PS 0.34 (1.01×10−14) 0.21 (0.54) 0.08 Any substance use disorder; hypertension; smoker; BMI
SM 0.38 (1.17×10−14) 0.19 (0.94) 0.08 Smoker; any alcohol use disorder; any substance use disorder; any anxiety disorder
PE(O) 0.38 (2.50×10−06) 0.16 (0.71) 0.06 Any depressive disorder
PE(P) 0.45 (6.96×10−09) 0.16 (0.70) 0.06 Any anxiety disorder; any depressive disorder

Bold indicates class surviving multiple testing correction.

BMI, body mass index; ERV, endophenotype ranking value; PI, phosphatidylcholine; LPE, lysophosphatidylethanolamine; LPC, lysophosphatidylcholine; PC(O), alkylphosphatidylcholine; PE, phosphatidylethanolamine; PC(P), alkenylphosphatidylcholine; PG, phosphatidylglycerol; LPC(O), lysoalkylphosphatidylcholine; PC, phosphatidylcholine; PS, phosphatidylserine; SM, sphingomyelin; PE(O), alkylphosphatidylethanolamine; PE(P), alkenylphosphatidylethanolamine.

*

Threshold of P<.1.