Fig. 3.

Data and interference management. ➀ Study enrollment will be performed after ICON has been obtained at the PCC. ➁ Data from the acute phase will be forwarded to ASCIS study coordination center. ➂ The PCC will inform the rehabilitation center of ASCIS patients. ➃ ASCIS data from the rehabilitation center will be forwarded either to the PCC (where data elements will be included in the CRF) or ➄ directly to ASCIS study coordination center. ➅ ASCIS study coordination center will remind the PCC about follow-up visits; data from the chronic phase will be forwarded to study coordination center. CRF case report form, ICON informed consent, PCC primary care center